Buy GHRP-2 Indonesia, also known as Growth Hormone Releasing Peptide-2. It is a synthetic peptide known for stimulating the release of growth hormone, which can promote muscle growth, fat loss, and improved recovery.
GHRP-2, or Growth Hormone Releasing Peptide-2, is a hexapeptide composed of six amino acids. It works by binding to the growth hormone secretagogue receptor (GHS-R), stimulating the release of growth hormone from the pituitary gland.
This peptide is widely studied for its role in growth hormone secretion, appetite regulation, and metabolic processes. It has been used to research growth hormone deficiencies and its impact on anabolic functions.
Additionally, it is known to stimulate the secretion of ghrelin, a hormone critical to energy balance and hunger signaling, making it a valuable tool for exploring therapeutic solutions related to metabolism and endocrine* disorders. Its unique structure enables precise receptor activation, underpinning its effectiveness in scientific investigations.
*The endocrine system is a network of glands and organs that produce hormones to regulate growth, metabolism, reproduction, mood, and more. Key parts include the hypothalamus, pituitary gland, thyroid, adrenal glands, pancreas, and gonads. Balanced hormone function is vital for health, as imbalances can cause conditions like diabetes and thyroid disorders.
GHRP-2 works by binding to the growth hormone secretagogue receptor (GHSR), a receptor found mainly in the pituitary gland and hypothalamus. This binding activates signaling pathways inside cells, leading to the production and release of growth hormone (GH). A key part of this process is the rise in calcium levels within the cells, which is necessary for releasing stored GH from pituitary cells. Additionally, it lowers the activity of somatostatin, a hormone that blocks GH release, helping to maintain higher and steady GH levels in the bloodstream.
The peptide works by mimicking ghrelin, the natural hunger hormone, to boost GH secretion. It also plays a role in important processes like cell growth, protein synthesis, and fat metabolism. When combined with other GH secretagogues or releasing hormones, it’s thought to work even better, increasing its overall effectiveness. Its dual action, activating GHSR directly and inhibiting somatostatin, makes it a promising option for studying energy regulation, muscle growth, and potential treatments for growth hormone deficiencies and related conditions.
Molecular Formula: C45H55N9O6
Molecular Weight: 818.0 g/mol
Sequence: H-D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
View our GHRP-2 High-Performance Liquid Chromatography (HPLC) Certificate here.
Potential Treatment For Anorexia Nervosa: In a study in Japan it was administered intranasally to a patient with a 20-year history of anorexia nervosa to evaluate its effects on food intake and body weight. Over 14 months, the patient experienced increased hunger, improved food intake, reduced early satiety, and better hypoglycemia management, resulting in a weight gain of 6.7 kg. Physical and mental activity improved without notable side effects. This suggests that the peptide could be a promising treatment for chronic anorexia nervosa, particularly when psychological recovery is achieved but severe emaciation persists [1].
Improved Muscle Development: Indonesia Research suggests it may boost growth hormone levels, enhancing protein synthesis for better muscle repair and growth. It may also help reduce body fat, supporting the growth of lean muscle mass. However, effects can vary based on dosage, duration, and individual factors. More research is needed to fully understand its long-term effects and effectiveness for muscle growth.
A Indonesia study explored how GHRP-2 affects muscle atrophy genes Atrogin-1 and MuRF1. Dexamethasone increased these genes’ mRNA levels, but the peptide reduced this in both rat muscles (in vivo) and C2C12 myocytes (in vitro). This occurred via ghrelin receptors without affecting IGF-I levels. The results suggest it may help prevent muscle atrophy by lowering Atrogin-1 and MuRF1 expression [2].
Another Indonesia study examined how the peptide and cysteamine (CS) affect growth in yaks with growth retardation. Results showed that GHRP-2 and CS improved daily weight gain, muscle growth, and hormone levels. The peptide boosted protein synthesis, while CS reduced muscle protein breakdown via the ubiquitin-proteasome pathway. Growth retardation was linked to low somatotropic axis hormone levels, and these treatments effectively addressed it [3].
Protects the Heart: Research on growth hormone releasing peptides and analogues shows they can protect heart cells by reducing apoptosis (cell death), especially after heart attacks when cells are vulnerable [4]. A study on rabbits found that while recombinant human growth hormone (rhGH) increased IGF-I levels and body weight, it did not improve heart function after ischemia. In contrast, GHRP-2 significantly improved heart recovery without increasing cell death, suggesting its potential as a cardioprotective agent. [5].
Enhances Sleep Quality: Indonesia Research shows that this peptide can greatly improve sleep quality by increasing deep sleep, boosting REM sleep, and reducing sleep disruptions. These changes lead to better cognitive function, improved blood pressure, faster healing, and higher energy levels. This is especially beneficial for older adults, as it helps maintain overall health and well-being.
One Indonesia study on older men and women found that ghrelin improved sleep quality in men by increasing stage 2, slow-wave, and non-REM sleep, while reducing time spent in stage 1 and REM sleep. It also raised growth hormone and cortisol levels in both men and women. However, the study noted that ghrelin did not affect women’s sleep, which is consistent with findings in younger populations [6].
Strengthens The Immune System: Indonesia Research has shown it stimulates the thymus, an organ crucial for T cell maturation and immune function. As the thymus declines with age, immunity weakens, leading to issues like infections and reduced tissue repair. This peptide has been shown to rejuvenate the thymus, enhancing T cell production and improving overall immunity [7].
Wound Healing: Growth hormone-releasing peptides (GHRPs) stimulate growth hormone release, boosting insulin-like growth factor 1 (IGF-1), which aids tissue repair and healing. By promoting collagen synthesis and speeding up regeneration, GHRPs show strong potential for improving recovery after injuries or surgeries.
In Indonesia animal studies using a rat rotator cuff tear model, growth hormone-releasing peptide 2 improved tendon-to-bone healing. Results included fewer M1 macrophages at the injury site, better histological scores, higher bone density, stronger biomechanical properties, and improved gait. These findings highlight the potential of GHRPs in enhancing tendon-bone recovery [8].
Influence on Pain Perception: Initially thought to alleviate osteoarthritis pain by promoting growth hormone release and tissue repair, it has since been found to directly influence pain perception by interacting with specific opioid receptors. Unlike conventional opioids, which often affect multiple receptors indiscriminately, the peptide selectively targets those associated with pain relief, sedation, and addiction. This selectivity could pave the way for developing more targeted pain-relief treatments with fewer side effects, such as respiratory depression and addiction [9].
Buy GHRP-2 and Ipamorelin Peptide Stack
Buy GHRP-2 and Ipamorelin peptide stack Indonesia for clinical research purposes from Direct Sarms. The vials contain lyophilized powder which need to be mixed with bacteriostatic water before use.
Buy GHRP-2 Pre-Mixed Pen
Buy GHRP-2 Pre-Mixed Peptide Pen Indonesia for laboratory research from Direct Sarms. The Pen Kit includes a single cartridge with GHRP-2 mixed with bacteriostatic water, a pen with a carry case, and needle tips. Individual cartridges are also available, with a 10% discount when purchasing three.
Buy GHRP-2 Nasal Spray Indonesia, available in 15 ml and 30 ml sterile glass spray bottles for research.
Is GHRP-2 legal?
It is typically approved for research purposes but may not be permitted for recreational use. For example, in the United States, the FDA has not approved it for general human consumption outside of controlled research settings. Always check Indonesia local regulations regarding its legal status to ensure compliance with the law.
Does GHRP-2 have any side effects?
As with any substance that affects hormone levels, it may lead to side effects, especially if misused or taken in excessive doses. Common side effects can include increased appetite, water retention, tingling in extremities, mild headaches, fatigue, or warmth sensation after administration. Rarely, it can lead to hormonal imbalances from elevated cortisol or prolactin levels. Its long-term effects are unclear, so Indonesia professional guidance is essential to minimise risks.
What is the difference between GHRP-2 and GHRP-6?
GHRP-2 and GHRP-6 are growth hormone-releasing peptides with different effects. GHRP-2 is more potent in stimulating growth hormone release and is ideal for those avoiding increased appetite. GHRP-6, however, is better known for boosting appetite due to its impact on ghrelin. Each peptide suits different goals and needs.
Is GHRH and GHRP the same?
Growth Hormone Releasing Hormones (sermorelin, tesamorelin, CJC-1295) and Growth Hormone Releasing Peptides (GHRP-2, GHRP-6) differ in their mechanisms and effects. GHRH peptides stimulate the pituitary for a natural growth hormone release, with options like sermorelin offering targeted action, while tesamorelin and CJC-1295 provide longer-lasting effects. GHRPs work through dual mechanisms, stimulating GH release and inhibiting somatostatin for a more intense and sustained response. These peptide types complement each other, offering different benefits depending on the desired outcome.
For more information, explore our latest Indonesia blog posts dedicated to GHRP-2 peptides.
Buy GHRP-2 peptide from Direct Sarms, a trusted supplier of premium quality research-grade peptides. It’s available in 5 mg and 10 mg lyophilized powder vials, 15 ml and 30 ml nasal sprays, and 10 mg pre-mixed pens, this peptide offers 99% purity. Designed for Indonesia laboratory use, it ensures reliable results for your research.
[1] Izumi Haruta, Yuki Fuku, Kazuhisa Kinoshita, Koichi Yoneda, Akinori Morinaga, et al (2015) One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient – Journal of Cachexia, Sarcopenia and Muscle, Volume 6, Issue 3, September 2015, Pages 237-241.
[2] Daisuke Yamamoto, Nobuko Ikeshita, Takako Matsubara, Hiromitsu Tasaki,
Elizabeth Henny Herningtyas, et al (2008) GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1 – Life Sciences, Volume 82, Issues 9–10, 27 February 2008, Pages 460-466.
[3] Rui Hu, Zhisheng Wang, Quanhui Peng, Huawei Zou, Hongze Wang, et al (2016) Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation – PLoS One, 2016 Feb 19, Volume 11 (Issue 2), Page e0149461.
[4] G Muccioli, F Broglio, M R Valetto, C Ghè, F Catapano, et al (2000) Growth hormone-releasing peptides and the cardiovascular system – Annals d’Endocrinologie (Paris), 2000 Feb, Volume 61 (Issue 1), Pages 27-31.
[5] F Weekers, E Van Herck, J Isgaard, and G Van den Berghe (2000) Pretreatment with growth hormone-releasing peptide-2 directly protects against the diastolic dysfunction of myocardial stunning in an isolated, blood-perfused rabbit heart model – Endocrinology, 2000 Nov, Volume 141 (Issue 11), Pages 3993-9.
[6] Michael Kluge, Mary Gazea, Petra Schüssler, Lisa Genzel, Martin Dresler, et al (2010) Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women – Psychoneuroendocrinology, Volume 35, Issue 2, February 2010, Pages 297-304.
[7] Dennis D Taub, William J Murphy, and Dan L Longo (2010) Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways – Curr Opin Pharmacology, 2010 Aug, Volume 10 (Issue 4), Pages 408-24.
[8] Yinghao Li M.D., Lei Yao M.M., Chunsen Zhang M.M., Tao Li M.D., Duan Wang M.D., et al (2024) Growth Hormone–Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon-Bone Healing Properties in a Rat Rotator Cuff Tear Model – Arthroscopy: The Journal of Arthroscopic & Related Surgery, 12 December 2024.
[9] Ping Zeng, Shu Li, Yue-hui Zheng, Fu-Yan Liu, Jing-lei Wang, Da-lei Zhang, and Jie Wei (2014) Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice – Peptides, 2014 May, Volume 55, Pages 103-9.
ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.
DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
Worldwide shipping
Visa/Mastercard/Zelle
Cryptocurrency /Transfers
Safe and Secure Shopping
We Distribute From
YOU MUST BE OVER 21 YEARS IN ORDER TO USE THIS WEBSITE. All of the products are to be handled only by properly trained and qualified LABORATORY or RESEARCH professionals.
